The clock-drawing test is used for screening for cognitive impairment and dementia and as a measure of spatial dysfunction and neglect. It was originally used to assess visuo-constructive abilities but we know that abnormal clock drawing occurs in o

This article presents a historical perspective of foundational studies utilizing near-infrared spectroscopy (NIRS) to measure the hemodynamics, oxygenation, and activation of the human brain cortex during cognitive tasks, called functional NIRS (fNIR

Alzheimer’s disease (AD) is the most common type of dementia and will be an increasing health prob-lem in society as the population ages. Mild cognitive impairment (MCI) is considered to be a prodromalstage of AD. The ability to identify subjects wit

Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the leading cause of dementia worldwide, and is characterized by the accumulation of amyloid plaques in the brain parenchyma. The plaques consist of abnormal deposits m