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详细说明： SNP概论及应用。Single-nucleotide polymorphism (SNP) is a new term for an old concept. Geneticists have been trying for decades to find the genetic differences among individuals. Originally phenotypes were used, then protein sequence, electrophoresis, restriction fragment polymorphisms (RFLPs), and microsatellites. With recent tech- nologies for DNA sequencing and the detection of single-base differences, we are approaching the time when all differences in DNA sequence among individuals can be found. The next challenge is to relate the se genetic differences to phenotypes such as disease risk and response to therapies. ...展开收缩
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